(BPT) - Developing healthier habits can begin with small, achievable steps that drive momentum toward eating well, being physically active and making the best choices for one’s overall wellness. More and more, people are turning to mobile applications as one-stop, readily-accessible resources to support their health and wellness goals. Today, nearly 46 million Americans currently use a mobile application like a fitness tracker or a calorie counter.^[i] Available via iTunes and Google Play for people living with type 2 diabetes, the INVOKANA^® (canagliflozin) Check Your Numbers healthy habits tracker application combines tools like medication, blood sugar and exercise trackers with encouraging tips to serve as a wellness partner—making staying motivated while managing type 2 diabetes easier to accomplish.

INVOKANA^® is a once-daily oral therapy used along with diet and exercise to lower blood sugar in adults with type 2 diabetes. INVOKANA^® has been proven to significantly lower A1C in adults with type 2 diabetes. In most clinical trials, the majority of people taking INVOKANA^® reached an A1C goal of less than 7.0, a goal recommended by the American Diabetes Association. INVOKANA^® works with the kidneys to help adults with type 2 diabetes lose some sugar through the process of urination. Although it’s not for weight loss or blood pressure management, in clinical trials INVOKANA^® was also shown to reduce body weight and systolic blood pressure, and was generally well tolerated. The most common side effects of INVOKANA^® include genital yeast infections, urinary tract infection, and changes in urination.^[ii]

The Check Your Numbers application was developed with support and feedback from real patients like Adam, who realized the benefits of the on-the-go resource in helping manage his type 2 diabetes.

“Like many, I have a busy lifestyle that sometimes makes managing my type 2 diabetes feel like a chore,” Adam said. “My phone is always less than an arm’s length away, so being able to set medication reminders and log my food choices, physical activity and blood glucose levels instantly makes a difference for me.”

For Adam, Check Your Numbers helps reinforce the importance of a healthy lifestyle in improving control over one’s diabetes with tracking features, including:

• Medication: Stay on top of treatment plans on a daily basis.
• Blood Glucose: Track blood glucose levels before and after meals to help identify patterns as well as A1C after doctor visits for a broad view of blood glucose over time.
• Diet: Record daily meals for insights on how to fine-tune healthy eating and support success.
• Exercise: Keep track of workouts to identify what activities, frequencies, and durations work best.

“The app acts like a digital diary that gives me a better view of my whole health—providing all of the necessary information right at my fingertips—and showcases my successes and areas for improvement really well,” Adam continued. “The tools help me make informed wellness choices that both my doctor and I appreciate.”

Get help with loving your numbers, and download the INVOKANA^® Check Your Numbers app today. Sign in, tap the mobile device’s screen and track important health metrics with the swipe of a finger. Visit Apple and Google Play stores to learn more about the INVOKANA^® Check Your Numbers app.

It is also important to stay up-to-date on coverage allowed by insurers and health plans for prescribed medications. Formulary coverage of INVOKANA^® is expanding rapidly, with preferred access for 80 percent of Commercial and Medicare Part D patients in the United States.^[iii]

WHAT IS INVOKANA^®?

INVOKANA^® is a prescription medicine used along with diet and exercise to lower blood sugar in adults with type 2 diabetes. INVOKANA^® is not for people with type 1 diabetes or with diabetic ketoacidosis (increased ketones in blood or urine). It is not known if INVOKANA^® is safe and effective in children under 18 years of age.

IMPORTANT SAFETY INFORMATION

INVOKANA^® can cause important side effects, including:

• Dehydration (the loss of body water and salt), which may cause you to feel dizzy, faint, lightheaded, or weak, especially when you stand up (orthostatic hypotension). You may be at higher risk of dehydration if you have low blood pressure, take medicines to lower your blood pressure (including diuretics [water pills]), are on a low sodium (salt) diet, have kidney problems, or are 65 years of age or older
• Vaginal yeast infection. Women who take INVOKANA^® may get vaginal yeast infections. Symptoms include: vaginal odor, white or yellowish vaginal discharge (discharge may be lumpy or look like cottage cheese), or vaginal itching
• Yeast infection of the penis (balanitis or balanoposthitis). Men who take INVOKANA^® may get a yeast infection of the skin around the penis. Symptoms include: redness, itching, or swelling of the penis; rash of the penis; foul-smelling discharge from the penis; or pain in the skin around penis

Talk to your doctor about what to do if you get symptoms of a yeast infection of the vagina or penis.

Do not take INVOKANA^® if you:

• are allergic to canagliflozin or any of the ingredients in INVOKANA^®. Symptoms of allergic reaction may include: rash; raised red patches on your skin (hives); or swelling of the face, lips, tongue, and throat that may cause difficulty in breathing or swallowing
• have severe kidney problems or are on dialysis

Before you take INVOKANA^®, tell your doctor if you have kidney problems; liver problems; pancreas problems; are on a low sodium (salt) diet; are going to have surgery; are eating less due to illness, surgery, or a very low calorie diet; ever had an allergic reaction to INVOKANA^®; drink alcohol very often (or drink a lot of alcohol in short-term); or have other medical conditions.

Tell your doctor if you are or plan to become pregnant, are breastfeeding, or plan to breastfeed. It is not known if INVOKANA^® will harm your unborn baby. It is also not known if INVOKANA^® passes into your breast milk.

Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take diuretics (water pills), rifampin (used to treat or prevent tuberculosis), phenytoin or phenobarbital (used to control seizures), ritonavir (Norvir^®, Kaletra^® – used to treat HIV infection), or digoxin (Lanoxin^®– used to treat heart problems).

Possible Side Effects of INVOKANA^®

INVOKANA^® may cause serious side effects, including:

• Ketoacidosis (increased ketones in your blood or urine) can happen with INVOKANA^®, even if your blood sugar is less than 250 mg/dL. Stop taking INVOKANA^® and call your doctor right away if you get any of the following symptoms: nausea, vomiting, stomach-area pain, tiredness, or trouble breathing
• Kidney problems, a high amount of potassium in your blood (hyperkalemia), or low blood sugar (hypoglycemia). If you take INVOKANA^® with another medicine that can cause low blood sugar, such as a sulfonylurea or insulin, your risk of getting low blood sugar is higher. The dose of your sulfonylurea medicine or insulin may need to be lowered while you take INVOKANA^®
• Serious Urinary Tract Infections: may lead to hospitalization and have happened in people taking INVOKANA^®. Tell your doctor if you have signs or symptoms of a urinary tract infection such as: burning feeling while urinating, need to urinate often or right away, pain in the lower part of your stomach (pelvis), or blood in the urine. Some people may also have high fever, back pain, nausea, or vomiting

Signs and symptoms of low blood sugar may include: headache, drowsiness, weakness, dizziness, confusion, irritability, hunger, fast heartbeat, sweating, shaking, or feeling jittery.

Serious allergic reaction. If you have any symptoms of a serious allergic reaction, stop taking INVOKANA^® and call your doctor right away or go to the nearest hospital emergency room.

Broken Bones (fractures): Bone fractures have been seen in patients taking INVOKANA^®. Talk to your doctor about factors that may increase your risk of bone fracture.

The most common side effects of INVOKANA^® include: vaginal yeast infections and yeast infections of the penis; urinary tract infection; or changes in urination, including urgent need to urinate more often, in larger amounts, or at night.

Tell your doctor if you have any side effect that bothers you or that does not go away. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects to Janssen Scientific Affairs, LLC at 1-800-526-7736.

Please see Medication Guide for important INVOKANA® (canagliflozin) product information.

Canagliflozin is licensed from Mitsubishi Tanabe Pharma Corporation.

Trademarks are those of their respective owners.

044335-151207

[i] Nielsen. “Hacking Health: How Consumers Use Smartphones and Wearable Tech to Track Their Health.” April 16, 2014. http://www.nielsen.com/us/en/insights/news/2014/hacking-health-how-consumers-use-smartphones-and-wearable-tech-to-track-their-health.html. Accessed January 6, 2016.

[ii] INVOKANA (canagliflozin). “Prescribing Information.” December, 2015. https://www.invokana.com/prescribing-information.pdf. Accessed January 6, 2016.

[iii] Data on file. Janssen Pharmaceuticals, Inc., Titusville, NJ.

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